Harvard Cryo-EM Center for Structural Biology

The Harvard Cryo-Electron Microscopy Center for Structural Biology (HC2EM) is a joint effort by Harvard Medical School, Dana-Farber Cancer Institute, Boston Children’s Hospital, and Massachusetts General Hospital to provide state-of-the-art cryo-EM instrumentation and expertise for the Harvard structural biology community. We are located on the Harvard Medical School campus in the basement of the Seeley G. Mudd building at: Room B04 250 Longwood Avenue, Boston MA 02115.  


Currently, two MarkIV Vitrobots for sample preparation are available for use and we are accepting new users for the Talos Arctica and Titan Krios microscopes. The facility houses two Titan Krios election microscopes and a Talos Arctica electron microscope, all equipped with Gatan K3 Summit direct electron detectors and Volta phase plates.

This user facility offers consultation and training by staff in specimen preparation, microscope operation, image acquisition, and data analysis.

Please contact cryoem@crystal.harvard.edu with any specific questions.