Coronavirus Update

Harvard Medical School released information about the lab re-entry process and re-entry strategies for the Molecular EM Suite and Harvard Cryo-EM Center have been reviewed and approved.  These guidelines are subject to change as more information is released.  We will keep our strategies for facility usage updated on the website and will send an email to our user list if major modifications are made. 

On October 13, both facilities moved to Phase 2B. 

During Phase 2B:

  • Continue to follow Phase 2 disinfection protocols posted in the facilities.
  • Experienced MEMS users will no longer need to wait for approval of their session in PPMS.  If you do not have access to a calendar, please contact Remya to have your User Rights updated in PPMS.
  • The Dry Pumping Station (DPS) will not have a scheduling calendar in PPMS.  Please follow the taped areas in the MEMS for maintaining social distance while using the DPS.
  • Training will resume in the MEMS and for the Vitrobots in the Cryo-EM Center using two models: Superuser training and Staff training, both described on our COVID-19 page.  All users are required to provide their own face shield or face dome prior to training.  The maximum occupancy of the rooms will remain at 1 person unless a training session is scheduled and enhanced PPE is in use.

**We are working to update our training list and are asking for continued patience as we confirm all requests for training.**

Our COVID-19 page provides the latest information about the facilities.  Please check the BCMPHarvard Medical School, and Harvard University websites for more details about the re-opening status.

The Harvard Cryo-Electron Microscopy Center for Structural Biology is a joint effort by Harvard Medical School, Dana-Farber Cancer Institute, Boston Children’s Hospital, and Massachusetts General Hospital to provide state-of-the-art cryo-EM instrumentation and expertise for the Harvard structural biology community. This user facility offers consultation and training by staff in specimen preparation, microscope operation, image acquisition, and data analysis. Currently, two MarkIV Vitrobots for sample preparation are available for use and we are accepting new users for the Talos Arctica and Titan Krios microscopes. The facility houses two Titan Krios election microscopes and a Talos Arctica electron microscope, all equipped with Gatan K3 Summit direct electron detectors.

Additionally, the Molecular Electron Microscopy Suite at Harvard Medical School is a separate user resource currently available to qualified researchers affiliated with Quad-based labs at HMS. This separate resource offers training and supervision in negative-stain and cryo-transmission electron microscopy. Equipment includes four transmission electron microscopes, two cryo plungers, and sample preparation areas. The Tecnai F20 and Polara F30 TEMs are each equipped with Gatan K2 Summit direct electron detectors.

If you have questions about access, services, or training, please email us at

Recent News


A Better Look: The development of cryo-EM has revolutionized structural biology

September 12, 2018
"Throughout history, observations of structure, from Hooke’s cells to the beaks of Darwin’s finches, have provided insights necessary to understand how life works. This is particularly true in structural biology, a discipline focused on visualizing life at its most fundamental. Discoveries of the atomic structures of important proteins and biological molecules have been among the most celebrated in science and have generated more than a dozen Nobel Prizes, new fields of research, and multibillion-dollar companies."

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