The Harvard Cryo-Electron Microscopy Center for Structural Biology is a joint effort by Harvard Medical School, Dana-Farber Cancer Institute, Boston Children’s Hospital, and Massachusetts General Hospital to provide state-of-the-art cryo-EM instrumentation and expertise for the Harvard structural biology community. This user facility offers consultation and training by staff in specimen preparation, microscope operation, image acquisition, and data analysis. Currently, two MarkIV Vitrobots for sample preparation are available for use and we are gradually inviting new users for the Talos Arctica and Titan Krios microscopes as they become available. Once complete, the facility will house 2 Titan Krios election microscopes and 1 Talos Arctica electron microscope, all equipped with Gatan K3 Summit direct electron detectors. Check out the blog in the main menu for current updates.

Additionally, the EM Suite at Harvard Medical School is a user resource currently available to qualified researchers affiliated with the Cell Biology and BCMP departments at HMS. This separate resource offers training and supervision in negative-stain and cryo-transmission electron microscopy. Equipment includes 4 transmission electron microscopes, 2 cryo plungers, and sample preparation areas. The Tecnai F20 and Polara F30 TEMs are each equipped with Gatan K2 Summit direct electron detectors.

Recent News

New position available at the Harvard Cryo-EM Center!

July 10, 2019

We are seeking a Research Assistant to join our team to work in the Harvard Cryo-EM Center and the EM Suite. This position will perform and/or coordinate a wide range of laboratory procedures independently and conduct a variety of complex support tasks determined by the needs of the two facilities, assuming a high level of responsibility for user training on a number of instruments and user database management.  There is also...

Read more about New position available at the Harvard Cryo-EM Center!

A Better Look: The development of cryo-EM has revolutionized structural biology

September 12, 2018
"Throughout history, observations of structure, from Hooke’s cells to the beaks of Darwin’s finches, have provided insights necessary to understand how life works. This is particularly true in structural biology, a discipline focused on visualizing life at its most fundamental. Discoveries of the atomic structures of important proteins and biological molecules have been among the most celebrated in science and have generated more than a dozen Nobel Prizes, new fields of research, and multibillion-dollar companies."