Cryo-EM @ Harvard Medical School
Two core facilities currently available to qualified researchers in the HMS community
B04 & B032 Seeley G. Mudd, 250 Longwood Ave, Boston MA 02115
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... Follow us at Twitter.com/HC2EM
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Structural basis of regulated m7G tRNA modification by METTL1–WDR4. It was great to be part of this Gregory Lab - @fischerlab1 collaboration. With amazing Jiazhi Li, @ssroyburman @HongYue88665668 @moritzhunkeler @HC2EM. #METTL1 #WDR4 #tRNA #Xray #cryoEM t.co/nTFmSQrkOt
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big thanks to the team: @michelleyfry @Navarro_PaulaP @VirlyAnanda5 @MakhloutaLugo @puspannehakim Bridget Luce, @fanfanYG @jlmcd_
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So excited that we finally have the ACTIVE NLRP3 inflammasome structure, thanks to super talented Le Xiao @LeXiao17, and Venkat Magupalli @MagupalliVenny! t.co/gUJA8QH5Kv t.co/CAJVbU1vu3
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@LeXiao17 solves the structure of the NLRP3 inflammasome with a tour de force purification and reconstitution strategy--bravo!! t.co/sK7xB3QDkw
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Cryo-EM structures of the active NLRP3 inflammasome disk t.co/mZt0C3Za0v
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Our first paper investigating the mechanism of the bacterial cell wall machinery. In this collaborative work with the Kruse and Bernhardt labs, we show how conformational dynamics of RodA-PBP2 coordinate its enzymatic activities. t.co/SnwZ8p4kF0
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Check out the @ColinLipper pre-print - Structural Basis for Selective Proteolysis of ADAM10 Substrates at Membrane-Proximal Sites t.co/y551IhU758
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@HHMINEWS Gilliam Fellow @JoseAVelilla2's beautiful structures of ClbP are out! Exciting collaboration with @BalskusLab, including @MatthewRVolpe and Grace Kenney, and Richard Walsh from @HC2EM helping with our first cryo-EM structure! More in thread (1/6) t.co/sud8FFIT4y
