During 2018, The Harvard Cryo-Electron Microscopy Center for Structural Biology will open with participation of Boston Children's Hospital, Dana-Farber Cancer Institute, and Massachusetts General Hospital. This separate facility will include 2 Thermo Scientific Titan Krios microscopes, a Thermo Scientific Talos Arctica microscope, Gatan K3 Summit direct electron detectors, additional sample preparation areas, and increased user support.
We are excited to say our microscope doors will be back open to masked users on June 21— no more squinting at multiple remote TeamViewer screens, and if you were trained remotely in recent months, you can finally see what the TEM-UI looks like in person (as long as you use hand sanitizer before you touch it)!
As we transition to being on-site during imaging sessions, inventory and grid drop offs are still expected 3 business days in advance for proposal sessions, and 1 week in advance for SAS and Rapid access...
Greetings to you all! We hope you are staying safe and healthy during these challenging times. Here's an update about how the Cryo-EM Center and the MEMS have been running during the shutdown.
Richard and Sarah have been rotating weeks on-site to clip and load samples and keep the microscopes cooled and aligned in the Cryo-EM Center. The on-site person has also been responsible for maintaining the disinfection routine we put in place on March 18th. Think about how many knobs, mice, keyboards, etc. you have to touch when you use a...
We are gradually making the Arctica available, beginning with inviting users who have previous experience with SerialEM to test our workflows and acquisition parameters. Once we are confident in our systems, we will open it up to all affiliated researchers.
LiudmilaLANExcited to share our work about discovering a novel NLRP3 oligomeric state in a form of a double ring cage! t.co/X50XcmEg4F
Our findings show that unlike other inflammasome sensors, endogenous full-length NLRP3 is not monomeric, but forms a membrane-associated double ring
sshaolabCheck out this potent cycloheximide derivative made and characterized by the @liaulab! A fun collaboration that made us think hard about RPF positions and learn how chemistry journals are not at all like biology ones. t.co/T9YAe1g0D2