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Structural basis of MsbA-mediated lipopolysaccharide transport

Journal Article

Structure basis for RNA-guided DNA degradation by Cascade and Cas3

Journal Article

Molecular Mechanism of V(D)J Recombination from Synaptic RAG1-RAG2 Complex Structures

Journal Article

Structural basis of respiratory complex adaptation to cold temperatures

Journal Article

High-resolution cryo-EM analysis of the yeast ATP synthase in a lipid membrane

Journal Article

X-ray and cryo-EM structures of the mitochondrial calcium uniporter

Journal Article

Structure Basis for Directional R-loop Formation and Substrate Handover Mechanisms in Type I CRISPR-Cas System

Journal Article

Emerging enterococcus pore-forming toxins with MHC/HLA-I as receptors

Journal Article

Best practices for managing large CryoEM facilities

Journal Article

Distinct conformational states of SARS-CoV-2 spike protein

Journal Article

Intervention strategies are urgently needed to control the SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2) pandemic. The trimeric viral spike (S) protein catalyzes fusion between viral and target cell membranes to initiate infection. Here we...

ABCG2 transports anticancer drugs via a closed-to-open switch

Journal Article

ABCG2 is an ABC transporter that extrudes a variety of compounds from cells, and presents an obstacle in treating chemotherapy-resistant cancers. Despite recent structural insights, no anticancer drug bound to ABCG2 has been resolved, and the mechanisms...

Mechanism of client selection by the protein quality-control factor UBE2O

Journal Article

The E2/E3 enzyme UBE2O ubiquitylates diverse clients to mediate important processes, including targeting unassembled `orphan' proteins for quality control and clearing ribosomes during erythropoiesis. How quality-control factors, such as UBE2O, select...