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Molecular Mechanism of V(D)J Recombination from Synaptic RAG1-RAG2 Complex Structures

Journal Article

Structure Basis for Directional R-loop Formation and Substrate Handover Mechanisms in Type I CRISPR-Cas System

Journal Article

Structural basis of MsbA-mediated lipopolysaccharide transport

Journal Article

Best practices for managing large CryoEM facilities

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High-resolution cryo-EM analysis of the yeast ATP synthase in a lipid membrane

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Structure basis for RNA-guided DNA degradation by Cascade and Cas3

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X-ray and cryo-EM structures of the mitochondrial calcium uniporter

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The structure of the yeast Ctf3 complex

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Kinetochores are the chromosomal attachment points for spindle microtubules. They are also signaling hubs that control major cell cycle transitions and coordinate chromosome folding. Most well-studied eukaryotes rely on a conserved set of factors, which...

Substrate processing by the Cdc48 ATPase complex is initiated by ubiquitin unfolding

Journal Article

The Cdc48 ATPase (p97 or VCP in mammals) and its cofactor Ufd1/Npl4 extract poly-ubiquitinated proteins from membranes or macromolecular complexes for subsequent degradation by the proteasome. How Cdc48 processes its diverse and often well-folded...

Architecture of autoinhibited and active BRAF-MEK1-14-3-3 complexes

Journal Article

RAF family kinases are RAS-activated switches that initiate signaling through the MAP kinase cascade to control cellular proliferation, differentiation and survival1-3. RAF activity is tightly regulated, and inappropriate activation is a frequent cause of...

Structure and activation mechanism of the BBSome membrane protein trafficking complex

Journal Article

Bardet-Biedl syndrome (BBS) is a currently incurable ciliopathy caused by the failure to correctly establish or maintain cilia-dependent signaling pathways. Eight proteins associated with BBS assemble into the BBSome, a key regulator of the ciliary...

Structural basis of ER-associated protein degradation mediated by the Hrd1 ubiquitin ligase complex

Journal Article

Misfolded endoplasmic reticulum (ER) proteins are retrotranslocated into the cytosol, polyubiquitinated, and degraded by the proteasome in a process known as ER-associated protein degradation (ERAD). ERAD of misfolded luminal ER proteins (ERAD-L) is...