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149 results
2025
Jonathan W. Markert, Jelly H. Soffers, and Lucas Farnung. 2025. “Structural Basis of H3K36 Trimethylation by SETD2 During Chromatin Transcription”. Science, 387, 6733, Pp. 528-33. doi:10.1126/science.adn6319
Jonathan W. Markert, Jelly H. Soffers, and Lucas Farnung. 2025. “Structural Basis of H3K36 Trimethylation by SETD2 During Chromatin Transcription”. Science, 387, 6733, Pp. 528-33. doi:10.1126/science.adn6319
During transcription, RNA polymerase II traverses through chromatin, and posttranslational modifications including histone methylations mark regions of active transcription. Histone protein H3 lysine 36 trimethylation (H3K36me3), which is established by...
Kheewoong " Baek, Rebecca J Metivier, and Shourya S Roy Burman. 2025. “‘Unveiling the Hidden Interactome of CRBN Molecular Glues’”. "Nature Communications", 16, Pp. "6831"
Kheewoong " Baek, Rebecca J Metivier, and Shourya S Roy Burman. 2025. “‘Unveiling the Hidden Interactome of CRBN Molecular Glues’”. "Nature Communications", 16, Pp. "6831"
"Induced proximity by molecular glues refers to strategies that leverage the recruitment of proteins to facilitate their modification, regulation or degradation. As prospective design of molecular glues remains challenging, unbiased discovery methods are...
2025. “Molecular Organization of the New World Arenavirus Spike Glycoprotein Complex”. doi:10.1038/s41564-025-02085-6
2025. “Molecular Organization of the New World Arenavirus Spike Glycoprotein Complex”. doi:10.1038/s41564-025-02085-6
Of the multiple arenaviruses that cause haemorrhagic fevers in the Americas, all lack reliable therapeutic options, and only one has a vaccine. The arenavirus glycoprotein complex (GPC) binds cellular receptors and mediates pH-dependent fusion of viral...
Petr Pelech, Paula P. Navarro, Andrea Vettiger, Luke H. Chao, and Christoph Allolio. 2025. “Stress-Mediated Growth Determines Escherichia Coli Division Site Morphogenesis”. Proceedings of the National Academy of Sciences, 122, Pp. e2424441122. doi:10.1073/pnas.2424441122
Petr Pelech, Paula P. Navarro, Andrea Vettiger, Luke H. Chao, and Christoph Allolio. 2025. “Stress-Mediated Growth Determines Escherichia Coli Division Site Morphogenesis”. Proceedings of the National Academy of Sciences, 122, Pp. e2424441122. doi:10.1073/pnas.2424441122
The bacterial wall is composed of peptidoglycan (PG) and distinguishes bacteria from eukaryotes. Hence, PG synthesis and remodeling are of special interest for the development of antibiotics. Bacterial division represents the most challenging PG...
Christopher Nardone, Jingjing Gao, Hyuk-Soo Seo, Julian Mintseris, Lucy Ort, Matthew C.J. Yip, Milen Negasi, Anna K. Besschetnova, Nolan Kamitaki, Steven P. Gygi, Sirano Dhe-Paganon, Nikhil C. Munshi, Mariateresa Fulciniti, Michael E. Greenberg, Sichen Shao, Stephen J. Elledge, and Xin Gu. 2025. “Structural Basis for the Midnolin-Proteasome Pathway and Its Role in Suppressing Myeloma”. Molecular Cell, 85, Pp. 2597-2609. doi:https://doi.org/10.1016/j.molcel.2025.05.030
Christopher Nardone, Jingjing Gao, Hyuk-Soo Seo, Julian Mintseris, Lucy Ort, Matthew C.J. Yip, Milen Negasi, Anna K. Besschetnova, Nolan Kamitaki, Steven P. Gygi, Sirano Dhe-Paganon, Nikhil C. Munshi, Mariateresa Fulciniti, Michael E. Greenberg, Sichen Shao, Stephen J. Elledge, and Xin Gu. 2025. “Structural Basis for the Midnolin-Proteasome Pathway and Its Role in Suppressing Myeloma”. Molecular Cell, 85, Pp. 2597-2609. doi:https://doi.org/10.1016/j.molcel.2025.05.030
Summary The midnolin-proteasome pathway degrades many nuclear proteins without ubiquitination, but how it operates mechanistically remains unclear. Here, we present structures of the midnolin-proteasome complex, revealing how established proteasomal...
Zishuo Yu, Pradeep Sathyanarayana, Cong Liu, Joel M.J. Tan, Pan Yang, Biswajit Das, Donald M. Coen, Philip J. Kranzusch, Joseph J. Loparo, and Jonathan Abraham. 2025. “Mechanisms of HSV-1 Helicase-Primase Inhibition and Replication Fork Complex Assembly”. Cell. doi:10.1016/j.cell.2025.11.041
Zishuo Yu, Pradeep Sathyanarayana, Cong Liu, Joel M.J. Tan, Pan Yang, Biswajit Das, Donald M. Coen, Philip J. Kranzusch, Joseph J. Loparo, and Jonathan Abraham. 2025. “Mechanisms of HSV-1 Helicase-Primase Inhibition and Replication Fork Complex Assembly”. Cell. doi:10.1016/j.cell.2025.11.041
2024
Marilina Sautu, Tobias Herrmann, Gustavo Scanavachi, Simon Jenni, and Stephen C. Harrison. 2024. “The Rotavirus VP5* VP8* Conformational Transition Permeabilizes Membranes to Ca2+”. PLOS Pathogens, 20, 4, Pp. 1-28. doi:10.1371/journal.ppat.1011750
Marilina Sautu, Tobias Herrmann, Gustavo Scanavachi, Simon Jenni, and Stephen C. Harrison. 2024. “The Rotavirus VP5* VP8* Conformational Transition Permeabilizes Membranes to Ca2+”. PLOS Pathogens, 20, 4, Pp. 1-28. doi:10.1371/journal.ppat.1011750
Rotaviruses infect cells by delivering into the cytosol a transcriptionally active inner capsid particle (a "double-layer particle": DLP). Delivery is the function of a third, outer layer, which drives uptake from the cell surface into small vesicles from...
João Coelho, Matthew CJ Yip, Keely Oltion, Jack Taunton, and Sichen Shao. 2024. “The ERF1 Degrader SRI-41315 Acts As a Molecular Glue at the Ribosomal Decoding Center”. Nature Chemical Biology
João Coelho, Matthew CJ Yip, Keely Oltion, Jack Taunton, and Sichen Shao. 2024. “The ERF1 Degrader SRI-41315 Acts As a Molecular Glue at the Ribosomal Decoding Center”. Nature Chemical Biology
Translation termination is an essential cellular process, which is also of therapeutic interest for diseases that manifest from premature stop codons. In eukaryotes, translation termination requires eRF1, which recognizes stop codons, catalyzes the...
Karanbir Pahil, Morgan Gilman, Vadim Baidin, Thomas Clairfeuille, Patrizio Mattei, Christoph Bieniossek, Fabian Dey, Dieter Muri, Remo Baettig, Michael Lobritz, Kenneth Bradley, Andrew Kruse, and Daniel Kahne. 2024. “A New Antibiotic Traps Lipopolysaccharide in Its Intermembrane Transporter”. Nature
Karanbir Pahil, Morgan Gilman, Vadim Baidin, Thomas Clairfeuille, Patrizio Mattei, Christoph Bieniossek, Fabian Dey, Dieter Muri, Remo Baettig, Michael Lobritz, Kenneth Bradley, Andrew Kruse, and Daniel Kahne. 2024. “A New Antibiotic Traps Lipopolysaccharide in Its Intermembrane Transporter”. Nature
Gram-negative bacteria are extraordinarily difficult to kill because their cytoplasmic membrane is surrounded by an outer membrane that blocks the entry of most antibiotics. The impenetrable nature of the outer membrane is due to the presence of a large...
Friederike Benning, Simon Jenni, Coby Garcia, Tran Nguyen, Xuewu Zhang, and Luke Chao. 2024. “Helical Reconstruction of VP39 Reveals Principles for Baculovirus Nucleocapsid Assembly”. Nature Communications, 15, 1, Pp. 250
Friederike Benning, Simon Jenni, Coby Garcia, Tran Nguyen, Xuewu Zhang, and Luke Chao. 2024. “Helical Reconstruction of VP39 Reveals Principles for Baculovirus Nucleocapsid Assembly”. Nature Communications, 15, 1, Pp. 250
Baculoviruses are insect-infecting pathogens with wide applications as biological pesticides, in vitro protein production vehicles and gene therapy tools. Its cylindrical nucleocapsid, which encapsulates and protects the circular double-stranded viral DNA...
May S. Freag, Mostafa T. Mohammed, Arpita Kulkarni, Hagar E. Emam, Krishna P. Maremanda, and Ahmed O. Elzoghby. 2024. “Modulating Tumoral Exosomes and Fibroblast Phenotype Using Nanoliposomes Augments Cancer Immunotherapy”. Science Advances, 10, 9, Pp. eadk3074. doi:10.1126/sciadv.adk3074
May S. Freag, Mostafa T. Mohammed, Arpita Kulkarni, Hagar E. Emam, Krishna P. Maremanda, and Ahmed O. Elzoghby. 2024. “Modulating Tumoral Exosomes and Fibroblast Phenotype Using Nanoliposomes Augments Cancer Immunotherapy”. Science Advances, 10, 9, Pp. eadk3074. doi:10.1126/sciadv.adk3074
Cancer cells program fibroblasts into cancer associated fibroblasts (CAFs) in a two-step manner. First, cancer cells secrete exosomes to program quiescent fibroblasts into activated CAFs. Second, cancer cells maintain the CAF phenotype via activation of...
Jaron A. M. Mercer, Stephan J. DeCarlo, Shourya S. Roy Burman, Vedagopuram Sreekanth, Andrew T. Nelson, Moritz Hunkeler, Peter J. Chen, Katherine A. Donovan, Praveen Kokkonda, Praveen K. Tiwari, Veronika M. Shoba, Arghya Deb, Amit Choudhary, Eric S. Fischer, and David R. Liu. 2024. “Continuous Evolution of Compact Protein Degradation Tags Regulated by Selective Molecular Glues”. Science, 383, 6688, Pp. eadk4422. doi:10.1126/science.adk4422
Jaron A. M. Mercer, Stephan J. DeCarlo, Shourya S. Roy Burman, Vedagopuram Sreekanth, Andrew T. Nelson, Moritz Hunkeler, Peter J. Chen, Katherine A. Donovan, Praveen Kokkonda, Praveen K. Tiwari, Veronika M. Shoba, Arghya Deb, Amit Choudhary, Eric S. Fischer, and David R. Liu. 2024. “Continuous Evolution of Compact Protein Degradation Tags Regulated by Selective Molecular Glues”. Science, 383, 6688, Pp. eadk4422. doi:10.1126/science.adk4422
Conditional protein degradation tags (degrons) are usually >100 amino acids long or are triggered by small molecules with substantial off-target effects, thwarting their use as specific modulators of endogenous protein levels. We developed a phage...